Led by the country's opposition bloc, Muslim conservatives have protested against the concert over Coldplay's support for the LGBTQI community.
Recently, they also pushed for the concert to be halted in solidarity with Palestinians killed in the Israel-Hamas war.
Communications Minister Fahmi Fadzil said he did not foresee any problem with Coldplay's first concert in Malaysia on Wednesday night.
Security has been beefed up for the show that is expected to bring 75,000 people to a stadium outside Kuala Lumpur.
When asked if a 'kill switch" to cut off power supply would be used, Fahmi said it had been discussed with the organisers.
"The prime minister has also said the band, you know, is very supportive of Palestine. So, we are upbeat about the concert today."
Chris Martin as been known to wear rainbow colours and wave pride flags during performances.
Malaysia introduced the kill switch measure recently after a controversy sparked by British band The 1975 in Kuala Lumpur in July.
The band's lead singer slammed the country's anti-gay laws and kissed a male band mate during their performance, sparking a backlash among Muslims and prompting the government to cut short a three-day music festival.
Prime Minister Anwar Ibrahim has justified allowing the Coldplay concert, telling parliament that "Coldplay is actually among the bands that support Palestine".
He noted the previous administration, before he took power in November 2022, had approved the concert.
The opposition Islamic party PAS has criticised Anwar's stance.
While Coldplay supported the Palestinian cause, it also encouraged hedonism, its information chief Ahmad Fadhli Shaari said.
PAS often protests against concerts by international artists that it said were incompatible with Muslim values.
Concert organiser Live Nation Malaysia reminded concert-goers a few days ago to be "mindful of local cultures and sensitivities" and refrain from displaying items that might cause discomfort to others.
Coldplay also met resistance from Muslims when they performed in Indonesia this month, with rallies slamming the band as an LGBTQI "propagandist".
Coldplay is renowned for interlacing its values with its shows, such as the band's push for environmental sustainability.
Lead singer Chris Martin has been known to wear rainbow colours and wave gay pride flags during performances.
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