The Thursday Murder Club actor celebrated her 80th birthday in July and admits she cannot abide the attitude that some have towards her at this stage of her life.
"The hardest part is the condescension. It really annoys me," Mirren said in an interview with The Times newspaper.
"If my husband and I are holding hands, someone might say, 'Oh, look. How sweet.' It's like, excuse my language, 'F*** off.'Â
"There's something very condescending about people's attitudes and I think they think they are being kind and generous. But they're not. They're being insulting."
Despite her grumbles, Mirren has no interest in trying to live forever.
The Oscar-winning star - whose younger brother Peter and stepson Rio Hackford both died of cancer in their 50s - said: "As you travel through life you realise death is absolutely part of life. And it's always tragic and it can happen when you're young.
"You can lose friends to terrible accidents. You can lose friends to self-inflicted things. You can lose friends to dysfunctions or diseases.
"The tech bros think their billions are somehow going to hold back time. They haven't learn my mum's lesson. It's a natural wave of life that has been going on for billions of years and it's been beautiful to be part of that wave.
"It's what humanity is all about the end. So it's important not to wimp out. You're not going to be 30 when you're 50. You're just not."
Mirren stars with Pierce Brosnan, Celia Imrie and Ben Kingsley in the new Netflix film The Thursday Murder Club, which is based on a novel by RIchard Osman.
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