Australia's former major champion produced a brilliant back-nine blitz to close with a five-under-par 66 and blow away the field in the shadows of Los Angeles' iconic Hollywood hills backdrop.
With a five-under stretch in five holes, Green finished with a 12-under 272 total, three strokes clear of in-form Swede Maja Stark (68).
Green stretched her streak to 16 consecutive sub-par rounds at the course to slam the door shut on her chasers.
In adding to her HSBC Women's World Champions success in Singapore, Green joins rampant world No.1 Nelly Korda as only the second player to notch multiple LPGA Tour victories in 2024.
The 27-year-old also joins greats Karrie Webb (41), Jan Stephenson (16) Minjee Lee (10) and Rachel Hetherington (eight) as only the fifth Australian to win at least five times on the LPGA Tour.After starting the day sharing the lead with compatriot Grace Kim, Green quickly established a two-shot advantage on the very first hole.
Green's birdie and Kim's bogey left Green with the outright lead, and she retained it all afternoon despite a strong challenge coming from Stark.
Hannah Green drains a birdie putt to start her final round in Los Angeles. (AP PHOTO)
Runner-up to Korda at last week's Chevron Championship, the year's first major, Stark was just one shot back after making birdies on the seventh and 13th holes as Green toiled mid-round with seven straight pars.
But a chip-in birdie on the par-3 12th broke the shackles for Green, who picked up another shot on 13 to nudge two strokes clear.
Stark received a huge break on the 15th when her bunker shot shattered into the pin and stopped dead for an easy birdie when a bogey looked more likely.
Green, though, more than held her nerve - she hit the go button with a spectacular eagle three on 15, followed by a fourth birdie of the day on 16.
In collecting a cheque for $US562,500 ($A858,659), the West Australian crashed through the $US5 million ($A7.6 million) career prize money earnings.
While Green rejoiced, Kim's horror weekend continued with a demoralising six-over 77 to slump to a share of 25th.
The 23-year-old had been four shots clear at the halfway point and on track to capture a second LPGA Tour title.
Instead Kim was reduced to a putting wreck, unable to fashion a single birdie all weekend.