The 31-year-old will continue playing in the WBBL and the Women's National Cricket League, and possibly the Women's Premier League in India, but has decided against playing for Australia again.
"The decision to step away from international cricket was a difficult one to make, but I feel now is the right time for me," Lanning said.
"I've been incredibly fortunate to enjoy a 13-year international career, but I know now is the right time for me to move on to something new.
"Team success is why you play the game, I'm proud of what I have been able to achieve and will cherish the moments shared with teammates along the way."
Meg Lanning has announced her international retirement after leading Australia to five World Cups.
Lanning, a seven-time World Cup winner and three-time Belinda Clark medallist amassed 8,352 runs from 241 international matches.
She led Australia in 182 matches, more than any other women's player, and captained the team to five World Cup crowns.
In what turned out to be her final international match, Lanning led Australia to the 2023 T20 World Cup title against South Africa in February.
After missing the Ashes in England earlier this year over health concerns, Lanning is back playing for the Melbourne Stars in the WBBL.
Lanning initially took a break from cricket last year following Australia's gold medal at the Commonwealth Games in Birmingham, returning for the home series against Pakistan in January.
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