The Australian No.1's smooth path eased further after his third-round opponent Lucas Pouille pulled out with a stomach injury less than an hour before the start of their third-round match on Saturday.
The ninth seed could celebrate a stress-free morning, knowing he's booked his second-week spot at SW19 without the worry of having to play a possibly troublesome opponent on a damp, potentially difficult No.3 court.
Pouille has the ability to make an impact at grand slams, having reached the semi-finals of the 2019 Australian Open, where he was dismantled by eventual champion Novak Djokovic in straight sets.
Frenchman Lucas Pouille made it to the semi-finals of the 2019 Australian Open. (AP PHOTO)
Meanwhile, the men battling for the right to face de Minaur in the fourth round - French world No.34 Arthur Fils and Russia's 44th-ranked Roman Safiullin - were still waiting in frustration to start their match amid more of the drizzle that's plagued the  event this year.
De Minaur enjoyed two three-set wins against fellow Australian James Duckworth and Spain's Jaume Maunar in his opening two matches and will be savouring the most comfortable passage to the last 16 he has ever enjoyed.
In his sixth Wimbledon, he's made the fourth round for just the second time, following his 2022 run.
De Minaur has moved a step closer to potentially meet either seven-time champion Djokovic or fellow Sydneysider Alexei Popyrin in the quarter-finals.
Popyrin and world No.2 Djokovic will meet on Centre Court later on Saturday in a repeat of their 2023 Australian Open clash, with the winner to meet either 15th seed Holger Rune or French qualifier Quentin Halys in the fourth round.
De Minaur is getting used to qualifying for the business end of grand slams, making the second week for the fourth successive tournament, but making the quarter-finals at Wimbledon would be new territory for the 25-year-old.
Pouille, the former French No.1 who has made a stirring return by battling through the qualifiers at Wimbledon, has been recently bedevilled by injuries.
He had actually been close to pulling out after feeling pain from his stomach muscles during his win over Adelaide's Thanasi Kokkinakis in the second round, but ignored the advice of his team to pull out and battled on.
He eventually emerged victorious only when Kokkinakis took a tumble on court and had to retire with a knee injury.
This was the first time in his 74 grand-slam singles matches that de Minaur has been given the bonus of a walkover win.
The only negative could be that he is not quite as battle-hardened as he could be after an early exit in the Queen's Club Championship.
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