The final major of the year gets underway on Sunday, August 24 (local time), with qualifying starting next Monday.
But the young guns can skip that phase after getting direct entry into the New York City tournament, with world No.8 Alex de Minaur leading the Australian charge.
West Australian Schoolkate broke into the ATP top 100 for the first time last week following a string of strong results, including a stand-out victory over world No.47 Joao Fonseca at the Toronto Masters - his first win over a top-50 opponent.
Now ranked 97, the 24-year-old just missed direct entry, ranked No.110 at the July 14 entry deadline.
Reaching the second round of the 2024 US Open, Schoolkate also made three Challenger finals this season, claiming titles in Brisbane and Ilkley, UK.
"It's such an amazing experience to play in the main draws of the grand slams - it's what we as players work towards, week in, week out so I'm excited and ready for the challenge in New York," Schoolkate said.
Gibson, 21, has also enjoyed a breakthrough year, peaking at world No.107 last month.
Also from WA, Gibson recently captured her 10th ITF singles title at the W75 event in Granby, Canada.
After securing her first grand slam main-draw win at the Australian Open, coming from a set down in a memorable debut at Melbourne Park, Gibson made her maiden Wimbledon main-draw appearance this year achieved by winning three rounds of qualifying.
"This is an incredibly rewarding acknowledgement for all the hard work my team and I have been putting in and for the results I've had this year," Gibson said of the Tennis Australia wildcard.
"I can't wait to get out there and give it my very best and make everyone proud."
Schoolkate and Gibson will join 12 other Australians - eight men and four women - in the main draw.
A further seven men and nine women will represent Australia in qualifying.
A singles wildcard has also been issued to Venus Williams, the champion in 2000 and 2001.
Now 45 the American will be the oldest singles entrant at the US Open since Renee Richards, then 47, in 1981.
Among other wildcards Brandon Holt, son of Tracy Austin, who won the women's singles in 1979 and 1981, received one for the men's event.
5°C