Sinner beat the Spaniard 6-2 6-3 6-1 in Saturday's third round, bringing to just 17 the number of games he has conceded in three matches during which he hasn't conceded a set.
That is the smoothest start to a Wimbledon men's singles in the Open era, eclipsing Roger Federer, the sainted darling of Centre Court, who had lost 19 games at this stage in 2004.
Jan Kodes, a semi-finalist in 1972, also lost 17 games, but the Czech also lost a set, and was one-set all in the opening round against Pato Rodriguez.
Sinner, who has barely broken sweat, even during the heatwave start to the championships, said of Federer: "I watched matches of him and the classics, the all-time classics.
"The tennis was a little bit different in a way of more serve and volleys back in the days. The grass was different.
"But I enjoyed it so much watching Roger play. I never played against him in an official match. But in the other way, how they played, it was amazing.
"About the games lost, this is whatever. I'm not looking at these kind of records. I know that everything can change very quickly from one round to the other."
The world No.1 is yet to have his serve broken, has faced just eight break points and has spent only five hours and 23 minutes on court so far, which is six minutes less than his French Open final defeat by Carlos Alcaraz last month.
However, the players he has faced to date are ranked 95, 93 and 52 with little experience at the All England Club. He now meets a Wimbledon veteran, former semi-finalist and 19th seed Grigor Dimitrov.
It is, though, 11 years since the Bulgarian reached the last four and he has not made a quarter-final here since.
Dimitrov has retired from matches through injury at the last three grand slams but looks fit enough now and reached the fourth round with a 6-3 6-4 7-6 (7-0) win over Austria's Sebastian Ofner.
The Italian renaissance continued with 22nd-seed Flavio Cobolli dispatching Czech 15th seed Jakub Mensik 6-2 6-4 6-2, and he'll next face Croatia's 36-year-old former finalist Marin Cilic, who continued his own revival after multiple knee surgeries with a 6-3 3-6 6-2 6-4 victory over Spain's Jaume Munar.
A third Italian man in the last-16 will be Lorenzo Sonego, who finally prevailed in the longest epic of the championships after five hours and four minutes, defeating American Brandon Nakashima 6-7 (5-7) 7-6 (12-10) 7-6 (7-2) 3-6 7-6 (12-10).
He'll play another American in the last-16 in the shape of big-serving left-hander Ben Shelton, who beat lucky loser Marton Fucsovics 6-3 7-6 (7-4) 6-2.
