The Bulldogs have been boosted by the return of Bruce and Bailey Smith, but Josh Schache and Lachie Hunter were forced to enter the AFL's health and safety protocols.
Bruce hasn't featured for the Bulldogs since tearing his ACL against the Bombers in round 21 last year, while Smith is available to play after serving his suspensions for headbutting an opponent and using illicit drugs.
The Saints lost Seb Ross and Marcus Windhager to the health and safety protocols.
Richmond recalled premiership stars Nick Vlastuin, Trent Cotchin and Noah Balta among five changes for Saturday's clash with North Melbourne at Marvel Stadium.
Tom Lynch (hamstring) and Ivan Soldo (hand) go out after being cut down in last week's after-the-siren loss to Gold Coast, while Jason Castagna, Thomson Dow, Maurice Rioli and Jake Aarts were all dropped.
Brisbane have made a whopping seven changes for Saturday's match against the Giants in Canberra.
Harris Andrews, Keidean Coleman, Noah Answerth, Dan McStay and Callum Ah Chee all return after missing last week's loss to Essendon while in the health and safety protocols, with Rhys Mathieson and Darcy Gardiner returning.
Ruckman Oscar McInerney becomes the latest Lion to enter the health and safety protocols, while Marcus Adams has been ruled out through injury.
The Giants lost Lachie Whitfield (hip), Phil Davis (hamstring) and Adam Kennedy (concussion).
Jacob Hopper returns for his first AFL match since round one after recovering from a knee injury while Jake Riccardi, Xavier O'Halloran and Connor Idun also return.Â
West Coast lost ruckman Nic Naitanui (knee soreness) for Sunday's encounter with Hawthorn at the MCG.
Willie Rioli (personal reasons) and Jack Petruccelle (hamstring) also go out.
Midfielder Jai Culley, the No.1 pick in the mid-season draft, will make his debut, making him the 46th player to appear for West Coast this season.
