Sheezel was put in a moonboot ahead of Sunday's match after picking up the injury during their loss to West Coast last round.
The 19-year-old did see out the game, finishing with 31 disposals and two goals.
"Harry suffered an ankle injury while attempting to smother a ball with his foot," North Melbourne's head of performance Kevin White said.
"He has been put in a moonboot to offload that foot for conservative management and to enable greater recovery."
Bulldogs ruck Tim English is definitely out though after also suffering an ankle injury in their 39-point loss to Adelaide.
Western Bulldog Tim English (r) has an ankle injury and will miss the clash against the Kangaroos. (Matt Turner/AAP PHOTOS)
The club has yet to determine a timeline on his return with scans confirming 'a moderate grade ligament injury', according to the Bulldogs head of sports medicine Chris Bell.
"Tim won't play this week, and we will work through a process across the next seven days to determine his return-to-play plan."
Two-time Richmond premiership player Tom Lynch won't feature again this season.
The 31-year-old has only played four matches this year after suffering multiple injuries.
Requiring surgery for a significant left hamstring injury sustained in round four, Lynch returned in round 14 against Hawthorn before straining the opposite hamstring.
Lynch also missed most of the 2023 campaign, again only playing four matches, with a foot injury.
Young St Kilda midfielder Marcus Windhager has also been ruled out for the season following a setback in his hamstring rehabilitation.
The 21-year-old will undergo surgery.
Elsewhere, GWS duo midfielder Stephen Coniglio (shoulder) and ruck Kieren Briggs (shoulder) are set to return for the match against Fremantle, while the Dockers could recall Josh Treacy (knee), Sean Darcy (knee) and Michael Walters (hamstring).
Brisbane's Eric Hipwood (groin), Hawthorn midfielder Changkuoth Jiath (calf), Port Adelaide forward Mitch Georgiades (quad), St Kilda's Mattaes Phillipou (illness), Richmond forward Marlion Pickett (hamstring) and Sydney defender Lewis Melican (hamstring) all face tests ahead of round 23.
Sydney wingman Justin McInerney, who has returned to running after suffering a posterior cruciate ligament injury against North Melbourne in round 18, is expected to miss another two to three weeks.
Taylor Walker (c) will miss the derby against Port after undergoing eye surgery. (Matt Turner/AAP PHOTOS)
Adelaide forward Taylor Walker will miss out on the upcoming Showdown against Port after undergoing laser eye surgery.
Walker suffered pupil damage after he was struck in the right eye during the third quarter of their win over the Bulldogs.
A specialist also discovered minor retina damage, with the club yet to determine whether Walker will play in their final game of the season against Sydney.
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