Backing up their season-opening 42-point win against Collingwood, the Demons had minimal trouble putting away the Giants 15.9 (99) to 3.4 (22).
They kicked three unanswered goals in the second term and then seven without response in the last quarter to blow GWS away and claim the 77-point result.
A stunning captain's contribution from Kate Hore proved exactly what her side needed. She was completely untouchable in a five-goal, 23-disposal outing.
What minimal help she needed she received from hard-working on-baller Tyla Hanks, who racked up 12 clearances and 30 touches to help the Demons take control in the middle after the Giants made a hot start.
GWS' Georgia Garnett goaled in the opening seconds but it was the last time the Giants would lead, with Hore slotting three majors in the first quarter alone.
The class difference between the sides was on full show in the second term as Melbourne dominated every facet of the contest and kept the Giants scoreless, with only some butchered chances in front of goal allowing the scores to remain somewhat close.
GWS stalwart Nicola Barr celebrated her 50th outing with a typically gritty display, standing up to prevent any more scoreboard damage with a team-high 23 possessions and nine clearances.
But the Demons closed the show in style, with Alyssa Bannan and Olivia Purcell producing classy snaps as they piled on late goals against a tiring opponent.
The powerful Demons have now won 11 straight games since round four last season and again look one of the sides to beat.
It's a different story for the Giants, who are 0-2 after falling to previously-winless Sydney last weekend.
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