Montana Ham, Laura Gardiner, Ally Morphett, Zippy Fish and Tanya Kennedy had a day out on Sunday at Henson Park as the Swans led from the start and won 11.10 (76) to 5.7 (37).
It broke their four-game losing run and was a step back for the improving Blues, who had only lost to unbeaten North Melbourne in their previous six matches.
After kicking four goals to one in the first quarter, Sydney killed the game off with three goals in four minutes at the start of the second, breaking out to a game-high lead of 40 points.
Sydney were dominating the midfield and four of their goals in the first half came directly from centre bounces.
Down by 38 at the main break, Carlton played their best football at the start of the third term when they tightened up on the free-running Swans.
The Blues hit back with three quick goals and only trailed by 20 after six minutes of the quarter.
But they were coming from too far back and Sydney kicked the last two goals of the term to confirm the win.
Gardiner racked up 43 possessions, just two short of the record set earlier this month by North Melbourne star Ash Riddell.
She also finished with six tackles and nine clearances.
But Ham just shaded Gardiner for best afield, kicking two goals amid her 25 possessions - 12 of them contested.
Kennedy laid a game-high seven tackles and kicked two goals, while Morphett had eight clearances in the ruck.
Fish was a livewire around the ground, with 20 possessions and a team-high six rebound 50s.
Round-six Rising Star nominee Poppy Scholz was a standout for Carlton.
Moved forward in the second term, she kicked three goals either side of halftime - including two in Carlton's purple patch at the start of the third.
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