England's all-time leading Test wicket taker was hit for 38 off his wicketless 20-ball stint on Wednesday as the Originals went down to a dramatic one-wicket defeat to Southern Brave on the penultimate ball.
Tymal Mills proved the star with bat and ball after his late partnership with Craig Overton saw the Brave home.
At 43 years and seven days, Anderson became the second-oldest player ever to take part in the 100-ball-a-side competition, behind only South African Imran Tahir, who was 43 years 149 days when he played for Birmingham Phoenix back in 2022.
The Originals batted first, with England white-ball stars Jos Buttler and Phil Salt dominating with a 48-run partnership which was only ended by Mills, who grabbed the key wicket of Buttler for 22 before he claimed another prize scalp of South African big hitter Heinrich Klaasen.
Mills finished with 3-22 after ending Salt's entertaining knock of 60 from 41 deliveries, while Mark Chapman (22) and Lewis Gregory (6) finished unbeaten as the hosts made 4-131.
Anderson bowled the first 10 balls of the innings for 10 runs but it was Sonny Baker who found a quick breakthrough to snare captain James Vince for six.
Former England opener Jason Roy was particularly hard on Anderson's bowling, smashing him for four fours and a six off his final 10 balls.
Roy eventually sliced onto the stumps from a teasing Baker delivery for 30 while Scott Currie continued to keep the Originals in the hunt with his excellent 4-28, featuring the wickets of Leus du Plooy, Laurie Evans, Chris Jordan and Michael Bracewell.
But a last-gasp effort from Mills and Craig Overton featured the pair smashing 25 from 11 deliveries.
Mills eventually fell, slogging out to Currie off Gregory, but new batter Reece Topley coolly smashed a boundary to seal a tight win with one delivery remaining.
