Norris extended his lead in the F1 championship from one point to nine after he won the earlier sprint race and Australian rival Piastri crashed out at Sao Paulo.
Piastri qualified only fourth for Sunday's main event, and in another boost to Norris, Max Verstappen - 39 points behind the British driver - was knocked out in Q1 and will start the 71-lap contest in Interlagos way back in 16th.
Kimi Antonelli joins Norris on the front row with Charles Leclerc third for Ferrari.
Just hours after Norris navigated a chaotic sprint race - with 24-year-old Piastri failing to score after he crashed out on the sixth lap - the Englishman was back on track bidding to keep his championship momentum going.
Norris was on the back foot after his first attempt in Q3 when he locked up on the entry to the opening corner and was 0.651 seconds slower than Piastri and in 10th.
But the British driver produced an impressive lap under pressure to soar to the top of the time sheets. He finished 0.174 seconds clear of Antonelli. Piastri was no match for Norris, ending the day more than three tenths off the pace.
"I put myself under unnecessary pressure after I locked up on my first run so more stressful than I would have like but I stayed calm and put it all together when it mattered," said Norris.
"We are in good form, the team have given me a great car, and when I am in a good rhythm and I can put it all together, I can be on top."
It means Piastri faces losing further ground to Norris, while Verstappen declared his championship challenge over following a dismal qualifying performance.
"I can forget about that," Verstappen said.
"Where we are starting, that is not going to work."
Verstappen started 17th at this event last year before delivering a drive for the ages to secure a win which put him on the brink of a fourth world crown.
Then, Verstappen revelled in the wet, but with clear conditions forecast for Sunday's race, he could be cast more than 50 points off the title pace - the equivalent of two wins - with just four to play and 108 points available.
Earlier in the day Piastri dipped his front-left tyre on to the kerb on the exit of the Senna Esses in the sprint race which sent him into a spin and an unavoidable date with the wall.
The golden rules to tackling a damp track - following an overnight storm in Sao Paulo - are to avoid white lines and taking too much kerb and Piastri failed to adhere to the latter.
The abused tyre barrier on the exit of turn three required repairs and the race was red-flagged.
"A silly mistake really," said the Australian.
"An unfortunate mistake. So that's it."
Piastri had held a 34-point lead at the summit of the standings following his win in the Netherlands on the final day of August.
But the Australian's campaign has unravelled since and his latest error comes after he crashed in qualifying in Azerbaijan in September and then on the first lap of the race in Baku, before he caused a pile-up in last month's sprint race in Austin which led to both him and team-mate Norris failing to finish.
