Mr Andrews stepped down as premier and as the member for Mulgrave in late September, triggering Saturday's by-election for the southeast Melbourne seat.
Dandenong mayor Eden Foster is running for Labor, while opposition staffer and previous Mulgrave candidate Courtney Mann is the Liberals' pick.
Labor holds the seat on a healthy 10.2 per cent two-party-preferred margin but it could be reduced by the loss of Mr Andrews after more than 20 years as the local member.
Premier Jacinta Allan said Ms Foster was a fabulous candidate, having grown up within Mulgrave's suburbs of Noble Park and Springvale.
Opposition Leader John Pesutto acknowledged Mulgrave was a safe Labor seat but said it was important for the Liberals to offer residents a choice.
Mr Pesutto could face internal leadership pressure if the Liberals fail to finish second on primary votes but insisted he was not fazed by the prospect.
It's polling day in the by-election to replace Daniel Andrews in the Victorian parliament.
Ian Cook, of shutdown Melbourne caterer I Cook Foods, is recontesting the seat as an independent after collecting the second most first-preference votes at last year's state election.
On Monday, the Supreme Court ruled former chief health officer Brett Sutton's order to shut down the business over the listeria-linked death of an 86-year-old woman was invalid because the health department did not observe procedural fairness.
But the judge dismissed the company's bid for damages.
Victorian Electoral Commissioner Sven Bluemmel warned of long queues on election day following a low uptake of early and postal voting.
Saturday marks the second Victorian state by-election this year after the Liberals retained the seat of Warrandyte in Melbourne's northeast following the retirement of veteran MP Ryan Smith.
Labor did not contest the Warrandyte poll.
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