South Australian police arrested a 22-year-old man and 27-year-old woman at a home in Torrensville in Adelaide's inner west on Tuesday night.
It followed a high-level investigation by Major Crime detectives, triggered by the attack on senior pediatrician Michael Yung at his Gilberton home early on Monday morning.
Dr Yung, 61, died surrounded by family at the Royal Adelaide Hospital on Tuesday afternoon.
The pair has been charged with murder, aggravated serious criminal trespass and commit theft using force, and are set to appear at the Adelaide Magistrates Court later on Wednesday.
Detectives are not seeking any other suspects.
Police said there was no connection between the suspects and those being sought for a recent crime spree across Adelaide.
Tributes flowed for Dr Yung, who was head of the Women's and Children's Hospital's pediatric intensive care medical unit.
"This is an absolute tragedy," SA Premier Peter Malinauskas said on X, formerly Twitter.Â
SA Health Minister Chris Picton said it was an incredibly sad day for the state's health family.
"Dr Michael Yung has been there for so many South Australian children and families at their darkest times - now it is time for all of us to be there for him and his family," he wrote on X.
Women's and Children's Health Network acting chief executive Rebecca Graham, in a note to staff, said Dr Yung would be greatly missed by the many families he had supported.
In lieu of flowers, she urged people to donate to the Kathryn Browne-Yung Scholarship fund Dr Yung set up in his late wife's honour.
"We thank our colleagues at the Royal Adelaide Hospital for providing our valued colleague with such compassionate care, but sadly his injuries were too great," Ms Graham said.
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