The 55-year-old Burpengary East man faces 117 charges including 19 counts each of rape and carnal knowledge (child under 16) and 54 counts of indecent treatment of a child under 16.
The horrific investigation was triggered in February 2022 when a woman alleged she had been abused by the bus driver.
Detectives raided the man's home and uncovered a cache of child exploitation material.
After months of painstaking investigations, police have so far identified 15 child victims.
Police will allege the offences against multiple victims occurred over three decades, between 1992 and 2022, in the Redcliffe Peninsula, Deception Bay and Burpengary areas.
The accused allegedly befriended his victims while working as a bus driver between 1983 and 2001.
The victims were between 13 and 15 at the time of the alleged offences.
The accused is expected to reappear before the Redcliffe Magistrates Court on July 17.
Detectives continue to appeal for further victims or anyone with information to contact Crime Stoppers or Policelink.
1800 RESPECT (1800 737 732)
National Sexual Abuse and Redress Support Service 1800 211 028
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