Francescos Giorgi, 40, was arrested after detectives raided a Gold Coast hinterland property on Thursday afternoon.
He has been charged with the murder of Mr Griffiths, 35, who was last seen alive in the Brisbane CBD in January before his mother reported him missing on Australia Day.
Giorgi's charges were mentioned in Brisbane Magistrates Court on Friday, and he has been remanded in custody to reappear in the same court on May 9.
He is the second man charged with Mr Griffiths' murder after a 40-year-old Tingalpa man.
Police believe Mr Griffiths was taken by car with other people to a Coopers Plains transport depot and his "last signs of life" were recorded about January 16 or 17.
His remains haven't been found, but his death is linked to that of 35-year-old Andrew Christopher Walsh, whose body was found encased in concrete at the same transport depot earlier this month.
"The current whereabouts of Lachlan James Griffiths remains unknown," detectives said in a statement on Monday.
Acting Detective Inspector Chris Knight said in early March that both men were known to police before their deaths.
The transport depot is the common link between the dead men, but detectives don't believe Mr Griffiths' remains are buried there.
"Detectives will continue to interview witnesses and progress investigative strategies including the review of CCTV footage and telephone data," police said on Thursday.
Mr Walsh was reported missing by family in the north Queensland town of Mossman in January, however detectives say he was last seen alive at Slacks Creek in November.
David Lee Tan, 39, and Dewald de Klerk, 27, and a 39-year-old Thagoona man have been charged with being an accessory after the fact of Mr Walsh's murder and misconduct by interfering with his corpse.
"Detectives are continuing their appeal for information from anyone in the community who may have information into the disappearances of both men to assist in these investigations," police said.
9°C