Two die in caravan fire in Brisbane's west

"Two people were unaccounted for and were found deceased within the caravan, which was completely destroyed with parts of the roof collapsed," police said in a statement.

Paramedics treated a man for burns to his hands, neck and shoulders and he was taken to hospital in a stable condition.

A crime scene has been declared as investigations continue to determine the cause of the fire and whether it is suspicious.

Queensland Police Inspector Karl Hahne said losing two people in this way made it "a very sad day".

He told reporters the man taken to Royal Brisbane and Women's Hospital had non-life threatening burn injuries. 

"That person is in a stable condition at the RBWH hospital, (the) burns are consistent with trying to escape the fire or potentially alert people to the fire."