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Graham Road has been re-opened to traffic.
UPDATE 3.10pm
An air ambulance is at the crash and Ambulance Victoria has confirmed they are treating one person at the scene. Major collision detectives from Melbourne are on their way.
UPDATE 2.45pm
Police have said Graham Road will be closed for up to six hours.
EARLIER 1.19pm
Police have confirmed two vehicles are involved in a collision at the corners of Curr Road and Graham Road.
Graham Road is currently closed to traffic between Scobie Road and Curr Road, and police are urging motorists to avoid the area.