The 12-4 win on the Gold Coast on Thursday night was far from pretty but it was a sweet victory for captain Isabelle Kelly and her team.
Queensland inflicted pain on NSW in the old interstate series when the competition between the teams was a one-match affair, winning 16 games in a row from 1999 before a draw in 2015.
State of Origin for women was born in 2018 and the first three-match series was in 2024.
Last year the Maroons won the final match of the series to deny the Blues a 3-0 result but not this time, in front of 11,816 fans.
Kelly was player of the match and said it was a poignant moment to "create the same history here" after she was part of the 2016 NSW team that beat Queensland for the first time on the same ground.
"I am pretty speechless," Kelly said.
"We didn't make it easy for ourselves but we got the job done.
"I knew this year there was something really special about our whole wider squad and every time we came together we supported each other and that showed in our six-week block.
"Everyone put in so much to make sure the end product was what we wanted, which was 3-0."
The Blues were powerful through the middle early courtesy of rampaging prop Ellie Johnston and elite lock Olivia Kernick.
Kernick ran for a stunning 211m and made 31 tackles in an extraordinary display.
NSW second-rower Jasmin Meakes won the Katrina Fanning Medal as player of the series and coach John Strange said it was well deserved.
"Jasmine was outstanding in every game and is such a competitor," he said.
Maroons Nathan Cross was proud of his young side and optimistic about the future but said "errors again" cost them.
NSW dominated possession and territory early but the hosts dug deep.
The issue for the Maroons was the errors in their own half that kept inviting the Blues into it.
Something had to give and brilliant half Jesse Southwell orchestrated a backline move that sent Blues centre Kelly in for the opening try.
Maroons winger Jasmine Peters scored after scintillating backline play by five-eighth Chantay Kiria-Ratu and debutant fullback Destiny Mino-Sinapati to level it up.
Kiria-Ratu and half Lauren Brown upped the ante in the second half but the Blues were up to the challenge.
After Southwell landed a penalty, Kelly's offload to Jayme Fressard had the elusive winger cutting back on a diagonal run to get the Blues out to an eight-point lead
The Maroons were without captain Tamika Upton, star winger Julia Robinson and tough forward Makenzie Weale due to injury.
Gold Coast product Mino-Sinapati, who replaced Upton, had an outstanding Origin debut with her darting and weaving running style and ball playing.
"I struggle to find words and superlatives for Destiny. She is a 10 out of 10 human being," Cross said.
"She is a ripper. Nothing surprised me tonight because she has done it at training and done the work."
NSW women join the three Blues men's sides to have won series 3-0, achieved in 1986, 1996 and 2000.