Nche missed last weekend's rollicking 67-30 victory over Argentina in Durban that has put the Springboks in pole position at the top of the table, and will be a significant boost to the scrum as he replaces Boan Venter.
South Africa will retain the title with a bonus-point victory over Argentina no matter what happens in the other match in Perth between Australia and New Zealand. Australia have an outside chance while Argentina are out of contention.
If New Zealand get a bonus-point win and South Africa collect four points, it will come down to points difference and the Springboks are currently +55 with the All Blacks -6.
Coach Rassie Erasmus is taking no chances in what is likely to be a fiery affair against the Argentines, after tempers boiled over on several occasions in Durban.
"They may be out of the title race but they have beaten the All Blacks, Wallabies, and British and Irish Lions this season, and it would be a big target for them to defeat us as well, so it's going to be another hard grind," Erasmus said.
Nche will pack down in the front row with Thomas du Toit and hooker Malcolm Marx.
Erasmus has again selected a 5-3 split between forwards and backs on the bench. Grant Williams, Bongi Mbonambi and Jesse Kriel — a combined 186 caps — have been added to the bench
South Africa (v Argentina):
15-Damian Willemse, 14-Cheslin Kolbe, 13-Canan Moodie, 12-Damian de Allende, 11-Ethan Hooker, 10-Sacha Feinberg-Mngomezulu, 9-Cobus Reinach, 8-Jasper Wiese, 7-Pieter-Steph du Toit, 6-Siya Kolisi (captain), 5-Ruan Nortje, 4-Eben Etzebeth, 3-Thomas du Toit, 2-Malcolm Marx, 1-Ox Nche,
Replacements: 16-Bongi Mbonambi, 17-Jan-Hendrik Wessels, 18-Wilco Louw, 19-RG Snyman, 20-Kwagga Smith, 21-Grant Williams, 22-Manie Libbok, 23-Jesse Kriel.
with AP