Epstein's refusal to answer questions in Giuffre's lawsuit against his longtime associate Ghislaine Maxwell was disclosed in a filing on Friday in Manhattan federal court, as part of a trove of documents being unsealed from the civil defamation case, which settled in 2017.
The Fifth Amendment of the United States Constitution gives people the right not to incriminate themselves.
Virginia Giuffre's lawyers say Jeffrey Epstein routinely answered "Fifth" to hundreds of questions. (AP PHOTO)
In the September 2016 filing, Giuffre's lawyers said Epstein routinely answered "Fifth" in a deposition that month to about 500 substantive questions they posed, and 100 substantive questions that Maxwell's lawyers posed.
Giuffre's lawyers said Epstein's refusal to answer extended to questions that posed no real risk of incriminating him - including whether he knew Maxwell, had in 2008 pleaded guilty in open court to a prostitution charge and was healthy enough to testify.
The questions also included at least three about Epstein's relationship with former US president Bill Clinton.
Lawyers for Epstein said in a subsequent filing, also released on Friday, that their client would have invoked the Fifth Amendment if called upon to testify at trial.
They cited among other reasons the "burdens" he would face, and the expected "media circus generated by Mr Epstein's personal appearance".
Epstein killed himself in a Manhattan jail cell in August 2019 at age 66 while awaiting trial on sex trafficking charges.
Several other people accused of aiding in his sexual abuses also invoked their rights against self-incrimination in various litigation related to him, Friday's unsealed filings show.
More than 180 documents including depositions, legal briefs and email chains from Giuffre's lawsuit have been released since Wednesday, under an order last month from US District Judge Loretta Preska in Manhattan, who oversaw the case.
US District Judge Loretta Preska ordered the release of documents from Virginia Giuffre's lawsuit. (AP PHOTO)
The documents name many of Epstein's victims, who were paid to give him and others massages in exchange for money.
Others named included people who worked with the financier, and a handful of celebrities and politicians linked to him.
In addition to Clinton, prominent people named in the documents include actor Kevin Spacey, magician David Copperfield and business executive Leslie Wexner.
None was accused in the documents of wrongdoing.
Several documents discussed the alleged activities of Britain's Prince Andrew, who Giuffre sued and accused of abusing her more than two decades ago when she was 17.
Andrew has denied Giuffre's accusations but settled her case for a reported Stg12 million ($A22 million) in 2022.
Maxwell is appealing her December 2021 conviction and 20-year prison sentence for aiding in Epstein's sexual abuses.
A federal appeals court in Manhattan could review her case as soon as March.
