The 2022 program is being billed as a return to form for the festival, following its cancellation in 2020 and speculation about its future in 2021.
Last year a public backlash forced organisers to pull a project by controversial Spanish artist Santiago Sierra that proposed soaking a British flag in the blood of Indigenous people.
Festival creative director Leigh Carmichael, who previously apologised for the Sierra project, says this year's program shows the event is back in form.
"We're beginning a new era of Dark Mofo, exploring the ideas of rebirth, reincarnation, and new life," he said.
The first week will feature works by US video artists Bill Viola and Doug Aitken, and new major exhibitions from Canadian Jeremy Shaw, Tasmanians Fiona Hall and AJ King, and Queenslander Robert Andrew.
Week two will see US multi-instrumentalist Lingua Ignota perform along with English space rock band Spiritualized as well as Deafhaven and Chelsea Wolfe.
Kim Gordon, a founding member of Sonic Youth, will perform songs from her 2019 solo album No Home Record, while musician and composer Nils Frahm will also premiere a show titled Music for Hobart.
Long-running elements of the event will return, including the nude solstice swim in the River Derwent and a winter feast on Hobart's waterfront.
A Reclamation Walk through the streets of Hobart, launched last year in response to the Sierra project controversy, will also make a comeback.
The full program will be announced in April and the festival will run from June 8-22.
