The home side leads the three-match series 1-0 after winning the opening game by five wickets at Rawalpindi, where left-arm spinner Arafat Minhas took 5-32 on his ODI debut.
Pakistan was unchanged, which meant spinners were expected to dominate at Gaddafi Stadium, which also hosts the third game on Thursday.
Depleted Australia went with three specialist spinners including Adam Zampa, who has recovered from the neck spasms which forced him to miss the first ODI.
Zampa replaced fast bowler Billy Stanlake.
Line-ups:
Pakistan: Sahibzada Farhan, Maaz Sadaqat, Babar Azam, Ghazi Ghori, Salman Ali Agha, Abdul Samad, Shadab Khan, Arafat Minhas, Shaheen Shah Afridi (captain), Haris Rauf, Abrar Ahmed.
Australia: Matthew Short, Alex Carey, Josh Inglis (captain), Matthew Renshaw, Marnus Labuschagne, Cameron Green, Oliver Peake, Nathan Ellis, Matthew Kuhnemann, Adam Zampa, Tanveer Sangha.
- With AP.
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