Saturday's operation comes hours after another man was rescued from the flooded cave on Friday night.
The five people rescued are among seven Lao nationals who had entered the cave in Xaisomboun province to prospect for gold, but their exit was blocked, leaving them trapped for more than a week.
Video footage showed rescuers guiding a mud-smeared man on Friday wearing a headlamp from the tight cave entrance.
It took about 37 minutes to bring him through the passages to safety, the team said in a Facebook post.
A team of volunteers from neighbouring Thailand joined the rescue efforts on Sunday and further reinforcements from France, Indonesia, Japan, Thailand and Australia, the group posted on Facebook.
Kengkard Bongkawong, a Thai cave diver involved in the mission, said in a Facebook post on Friday the health of the survivors was deteriorating as they awaited rescue.
"The rescue operation is extremely challenging, as it involves moving them through narrow passages stretching hundreds of metres and requiring underwater diving," he said.
Footage taken on Thursday by Norrased Palasing, another Thai volunteer, showed survivors sitting on a ledge deep in the cave and crying with relief.
Reuters was able to confirm the location from corroborating social media footage showing two divers in the video both went into the cave for the rescue.
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